As an Authorized Service Provider for NimbleGen Sequence Capture Arrays, SeqWright can utilize this technology in concert with its next generation genomics capabilities to capture, amplify and sequence up to 30MB per 2.1M array of client-specified gDNA from the human (hg18) genome. The captured DNA can be derived from one contiguous region of the genome or from thousands of non-contiguous segments (>250bp). This technology enables customized genomic enrichment and subsequent analysis which results in significant decreases in time and expense while maintaining quality and sensitivity. There are two options for custom arrays: the 2.1M custom array which captures up to 30MB of sequence and the 385K custom array which captures up to 5MB of sequence.

The 2.1M Human Exome Array contains 2.1 million long-oligo features which enables the entire human exome, all 180,000 exons, to be captured on a single array. The array captures some 550 miRNA's as well. These arrays are pre-designed, validated and ready to go which means the turnaround time from sample preparation, to enrichment, to next generation sequencing only takes a matter of weeks. That is very significant considering complete exonic amplification and sequencing may have taken a year or more prior to the development of this technology.

The applications of sequence capture array, targeted enrichment and microfluidic technology combined with next generation genomics are as broad as they are powerful. They enable the average researcher to take on projects from multifactorial diseases studies to the analysis of multiple gene sets involved in specific metabolic pathways. General applications of these technologies include: